VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future DirectionsReview Published on 2023-04-062023-06-10 Journal: Biomedicines [Category] Fulltext, 원숭이두창, [키워드] development discovery F13L NIOCH-14 tecovirimat. VP37 protein [DOI] 10.3390/biomedicines11041106 PMC 바로가기 [Article Type] Review
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trialArticle Published on 2022-12-012022-10-06 Journal: The Lancet Regional Health - Western Pacific [Category] 진단, [키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded [DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article
Development of a magnetic nanoparticle-based method for concentrating SARS-CoV-2 in wastewaterArticle Published on 2022-11-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome affected applicability applied comparable Concentration coronavirus detect Detection sensitivity development Epidemiology limitations log magnetic nanoparticle Mild MNP Modification MS2 Pegcision Polyethylene glycol Polyethylene glycol precipitation polymerase chain Pseudomona quantified reducing SARS-CoV-2 SARS-CoV-2 RNA sensitivity virus virus virus concentration viruses Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.157613 PMC 바로가기
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of AgeArticle Published on 2022-11-032022-11-15 Journal: The New England Journal of Medicine [Category] Fulltext, MERS, 변종, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Administered administration Adults Adverse age assigned authority B.1.1.529 children circulating Cohort cohorts coronavirus coronavirus disease criteria determine development dose duration of follow-up Efficacy elicited evaluate evaluated event geometric mean concentration immune response incidence Infection injection median Month mRNA-1273 mRNA-1273 vaccine neutralizing antibody observer-blinded open label Part phase 3 trial Placebo placebo-controlled predominant Randomly reactogenicity receive Safe Secondary objective selected the vaccine Trial Vaccine variant Year [DOI] 10.1056/NEJMoa2209367 PMC 바로가기
Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
Global Regulatory and Public Health Initiatives to Advance Pediatric Drug Development for Rare DiseasesArticle Published on 2022-11-012022-11-16 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] advance affected approach children clinical trials COVID-19 COVID-19 pandemic development disease drug ecosystem Efficacy effort engage equity facilitate Follow-up include initiative key factor lack outcome measure Patient pediatric pediatric drug development promote Public public health rare disease rare diseases Regulatory Regulatory policy. Study design Therapies Trial trials [DOI] 10.1007/s43441-022-00409-w PMC 바로가기
Clinical characteristics of pediatric patients with COVID-19 between Omicron era vs. pre-Omicron eraResearch article Published on 2022-11-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 변종, [키워드] 113 patient center Characteristics Child children children with COVID-19 clinical Clinical characteristics clinical manifestation conducted Coronavirus disease 2019 Croup Delta variant of concern development diagnosed died disease evaluate less mechanical ventilation Most patient Older omicron Omicron variant Omicron variant of concern participant Patient Pediatric patient required Result retrospective rhinorrhea sore throat symptomatic patient syndrome underlying disease variant vomiting with COVID-19 [DOI] 10.1016/j.jiac.2022.07.016 [Article Type] Research article
Development of multiplex S-gene-targeted RT-PCR for rapid identification of SARS-CoV-2 variants by extended S-gene target failureArticle Published on 2022-11-012022-11-15 Journal: Clinica chimica acta; international journal of cli [Category] SARS, 변종, 치료기술, 치료제, [키워드] binding caused codon concordance rate Delta development Epidemics genomic sequencing Internal control Japan multiplex Multiplex RT-PCR Mutation N-gene omicron probe Rapid Rapid screening Region RT-PCR S-gene S-gene mutations S-gene target failure SARS-CoV-2 SARS-CoV-2 variant screening method Sequencing time-consuming Variant of concern. VoC VOCs [DOI] 10.1016/j.cca.2022.08.031 PMC 바로가기